I’m one of the few physicists I know who likes Thomas Kuhn. He was partly a historian of science, partly a sociologist. He got the basic idea right of what happens when the scientific paradigm shifts. A radical change of perspective suddenly occurs. Wholly new ideas, concepts, abstractions and pictures become relevant. Relativity was a big paradigm shift. Quantum mechanics was a big paradigm shift. So we keep on inventing new realisms. They never completely replace the old ideas, but they do largely replace them with concepts that work better, that describe nature better, that are often very unfamiliar, that make people question what is meant by “reality.” Then the next thing comes along and turns that on its head. And we are always surprised that the old ways of thinking, the wiring that we have or the mathematical wiring that we may have created, simply fail us.
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Leonard Susskind, in "Bad Boy of Physics", Interview by Peter Byrne, Scientific American (July 2011)