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To be sure, risks abound; but no one is proposing compassionate stewardship of ecosystems by philosophers. Humans are capable of choosing our own future pain-sensitivity too; but any species-wide genomic shift in human pain tolerance will depend on the willingness of prospective parents to use preimplantation genetic screening.

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Compassionate Biology: How CRISPR-based gene drives" could cheaply, rapidly and sustainably reduce suffering throughout the living world", BLTC Research, 2016

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